Reaktionsgleichung
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH:10]=[CH:11][C:12](=[O:13])[C:6]=2[CH:5]=1)([O-:3])=[O:2].CC(C)(O)[C:18]#[N:19]>>[N+:1]([C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH:10]([C:18]#[N:19])[CH2:11][C:12](=[O:13])[C:6]=2[CH:5]=1)([O-:3])=[O:2]Komponenten
Versuchsvorschrift
The novel process of the invention for the preparation of a compound of formula I wherein X is nitro comprises reacting 3-nitro-8,9-dihydro [5H] benzocycloheptene-5-one of the formula ##STR3## with acetone cyanhydrin of the formula to obtain 3-nitro-5-oxo-6,7,8,9-tetrahydro [5H] benzocycloheptene-7-carbonitrile of the formula ##STR4## reducing the latter with diborane in an organic solvent to obtain 3-nitro-7-aminomethyl-6,7,8,9-tetrahydro [5H] benzocycloheptene-5-ol of the formula ##STR5## deshydrating the latter to form 2-nitro-6,7-dihydro [5H] benzocycloheptene-7-methanamine of the formula ##STR6## and either reacting the latter with formic aldehyde and sodium cyanoborohydride to obtain N,N-dimethyl-2-nitro-6,7-dihydro [5H] benzocycloheptene 7-methanamine of the formula ##STR7## which may be reacted with an alkyl chloroformate of the formula
Aufarbeitung
- customThe novel process of the invention for the preparation of a compound of formula I wherein X
Quellen und Nachweise
- ORD-Eintrag
- ord-5f28c8fa63124e45bd3c38950184f27f
- Quelldatensatz
- uspto-grants-1978_09
- Patentnummer
- US04117164
Verknüpfte Notizen
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