Lithium Hydroxide → HCID 11214276, Verbindung
Reaktionsgleichung
C([O:5][C:6](=[O:39])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH:18]([C:23]3[S:27][C:26]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=4)=[N:25][C:24]=3[CH3:38])[CH2:19][CH2:20][CH2:21][OH:22])[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[OH:22][CH2:21][CH2:20][CH2:19][CH:18]([C:23]1[S:27][C:26]([C:28]2[CH:29]=[CH:30][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:32][CH:33]=2)=[N:25][C:24]=1[CH3:38])[O:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][N:8]2[CH2:7][C:6]([OH:39])=[O:5])=[CH:12][CH:13]=1Komponenten
3
Versuchsvorschrift
In analogy to the procedure described in example 2 c], [rac]-(6-{4-hydroxy-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-butoxy}-indol-1-yl)-acetic acid tert-butyl ester was treated with LiOH to obtain [rac]-(6-{4-hydroxy-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-butoxy}-indol-1-yl)-acetic acid as brown crystals.
Quellen und Nachweise
- ORD-Eintrag
- ord-5ebe70d88e9b4a43b988bd29f39f96e6
- Quelldatensatz
- uspto-grants-2007_06