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4-Morpholinocarbonyl-2-(1-naphthylmethylene)butyric acid → 4-Morpholinocarbonyl-2-(1-naphthylmethyl)butyric acid

HRID 1768595
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1768595
[O:1]1[CH2:6][CH2:5][N:4]([C:7](=[O:25])[CH2:8][CH2:9][C:10](=[CH:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)[C:11]([OH:13])=[O:12])[CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[O:1]1[CH2:2][CH2:3][N:4]([C:7](=[O:25])[CH2:8][CH2:9][CH:10]([CH2:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)[C:11]([OH:13])=[O:12])[CH2:5][CH2:6]1
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Komponenten

5

Edukt 2

HCID 538910904-Morpholinocarbonyl-2-(1-naphthylmethylene)butyric acidHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 189483864-Morpholinocarbonyl-2-(1-naphthylmethyl)butyric acidAusbeute 89,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

5 g (14.8 mmole) of the 5-morpholino-2-(1-naphthylmethylene)-5-oxopentanoic acid (prepared as described above) were dissolved in 50 ml of methanol and hydrogenated in an atmosphere of hydrogen at atmospheric pressure and in the presence of 1.0 g of a 10% w/w palladium-on-carbon catalyst. The catalyst was then removed by filtration, and the solvent was removed by distillation under reduced pressure. The residue was triturated with diethyl ether to precipitate crystals, which were collected by filtration to give 4.5 g of 5-morpholino-2-(1-naphthylmethyl)-5-oxopentanoic acid as white crystals, melting at 130°-135° C.

Aufarbeitung

  1. customThe catalyst was then removed by filtration
  2. customthe solvent was removed by distillation under reduced pressure
  3. customThe residue was triturated with diethyl ether
  4. customto precipitate crystals, which
  5. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-dbe538b0e69740818462049c57e8a4ad
Quelldatensatz
uspto-grants-1995_01
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05378690

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