Iodine → 2,6-diethyl-3-iodo-4(1H)-pyridone
Reaktionsgleichung
[I:1]I.[CH2:3]([C:5]1[NH:6][C:7]([CH2:12][CH3:13])=[CH:8][C:9](=[O:11])[CH:10]=1)[CH3:4].[OH-].[Na+]>O>[CH2:3]([C:5]1[NH:6][C:7]([CH2:12][CH3:13])=[CH:8][C:9](=[O:11])[C:10]=1[I:1])[CH3:4]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Iodine (720 mg) was added to a solution of compound F (430 mg) and sodium hydroxide (120 mg) in water (15 ml) and the mixture was stirred for 1 hour. The precipitated solid was collected by filtration and purified by flash chromatography, eluting with methanol/dichloromethane (1:19 v/v), to give 2,6-diethyl-3-iodo-4(1H)pyridone (G) (290 mg), m.p. 225°-227° C.; NMR (d6 -DMSO): 1.15(t, 6H), 2.5(q, 2H), 2.8(q, 2H), 5.9(s, 1H), 11.4(br s, 1H).
Aufarbeitung
- filtrationThe precipitated solid was collected by filtration
- custompurified by flash chromatography
- washeluting with methanol/dichloromethane (1:19 v/v)
Quellen und Nachweise
- ORD-Eintrag
- ord-d4b1b553c4424f56ba118ec77cb90a37
- Quelldatensatz
- uspto-grants-1995_01
- Patentnummer
- US05380730
Notizen zur Reaktion
Wird geladen…