Triethylamine → Ethoxycarbonylpropyleneurea

Reaktionsgleichung

[CH2:1]1[CH2:7][NH:6][C:4](=[O:5])[NH:3]C1.[CH2:8]([O:10][C:11](Cl)=[O:12])[CH3:9].[CH2:14](N(CC)CC)C>ClC(Cl)C>[CH2:8]([O:10][C:11]([CH2:14][CH:7]([NH:6][C:4]([NH2:3])=[O:5])[CH3:1])=[O:12])[CH3:9]

Komponenten

Versuchsvorschrift

Propyleneurea of 30.0 g (0.3 mol), ethylchloroformate of 10.9 g (0.1 mol) and dichloroethane of 100 g were charged in a reaction vessel and refluxed at 85° to 88° C. A solution of triethylamine of 10.1 g (0.1 mol) in dichloroethane of 250 g was added drop by drop to the refluxed mixture in 2.5 hours followed by continuing for further 2 hours. The resulting solution was condensated and a crude product was refined by the column chromatography to obtain ethoxycarbonylpropyleneurea of 2.2 g (12.7%).