Acetonitrile → HCID 117902772, Verbindung

HRID 1772171Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1772171
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[N:5]2[CH:11]=1.[I:12]N1C(=O)CCC1=O.C(#N)C>C(Cl)Cl>[I:12][C:11]1[N:5]2[C:6]([CH3:10])=[CH:7][CH:8]=[CH:9][C:4]2=[N:3][C:2]=1[CH3:1]

Komponenten

5

Edukt 3

HCID 6342AcetonitrileHCID 120273N-IodosuccinimideHCID 1386822,5-Dimethylimidazo(1,2-a)pyridine

Produkt 1

HCID 117902772HCID 117902772, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 2,5-dimethylimidazo[1,2-a]pyridine (0.5 g, 3.4 mmol), N-iodosuccinimide (770 mg, 3.4 mmol) and ACN (5 ml) is stirred at RT for 45 minutes. The mixture is diluted with DCM and extracted with an aqueous solution sodium thiosulfate. The combined organic layers are dried over MgSO4 and concentrated in vacuo. The product is purified by RP HPLC. Yield: 775 mg (83%). HPLC-MS: M+H=273; tR=1.02 min (METHOD—1).

Aufarbeitung

  1. extractionextracted with an aqueous solution sodium thiosulfate
  2. dry with materialThe combined organic layers are dried over MgSO4
  3. concentrationconcentrated in vacuo
  4. customThe product is purified by RP HPLC

Quellen und Nachweise

ORD-Eintrag
ord-039d71eed34f48048ad1f5b66bb0b01a
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09249151B2

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