Methylamine → Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester

HRID 1773741

Reaktionsgleichung

Reaktionsgleichung von HRID 1773741
F[C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(=O)([O-])[O-].[K+].[K+].[CH3:21][NH2:22]>C(Cl)Cl.O>[CH3:21][NH:22][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Komponenten

6

Edukt 3

HCID 6329MethylamineHCID 11430Potassium CarbonateHCID 13470961Methyl 2-fluoro-3-nitrobenzoate

Produkt 1

HCID 59635415Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Methyl 2-fluoro-3-nitrobenzoate (25 g, 0.126 mol) was dissolved in DCM (400 ml) and to this was added Potassium carbonate (34.7 g, 0.25 mol) followed by Methylamine (20.63 ml, 0.5 mol). Reaction was stirred at room temperature under argon. Upon completion reaction was diluted with water and extracted with DCM (3×) then dried over magnesium sulfate. Solvents were removed under reduced pressure to afford methyl 2-(methylamino)-3-nitrobenzoate as a yellow solid.

Aufarbeitung

  1. customReaction
  2. customUpon completion reaction
  3. extractionextracted with DCM (3×)
  4. dry with materialthen dried over magnesium sulfate
  5. customSolvents were removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7b54cf94915f4dfb8c875f28ccffe5d3
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09255089B2

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