Hydrochloric Acid → 3-Methyl-3-phenylbutan-2-one

HRID 1773908Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1773908
CON(C)[C:4](=[O:14])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH3:6].[Li]C.[CH3:18]COCC.Cl>C1COCC1>[CH3:6][C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[C:4](=[O:14])[CH3:18]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59788661N-Methoxy-N-methyl-2-phenyl-isobutyramideHCID 178418348HCID 178418348, Verbindung

Produkt 1

HCID 2854623-Methyl-3-phenylbutan-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of N-methoxy-N-methyl-2-phenyl-isobutyramide (example 207E) (16 g, 77.2 mmoles) in THF (300 mL) cooled at −50° C. is added dropwise a 1.6M solution of MeLi in Et2O (80 mL, 131.2 mmoles). The reaction mixture is allowed to reach 0° C. and 1N HCl (130 mL, 130 mmoles) is added. The aqueous phase is extracted with Et2O. The organic phase is washed with brine, dried over MgSO4, filtered and the solvent is removed under reduced pressure to give 3-methyl-3-phenyl-butan-2-one.

Aufarbeitung

  1. customto reach 0° C.
  2. extractionThe aqueous phase is extracted with Et2O
  3. washThe organic phase is washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customthe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-df5282149dc0482aa6d17b1b3e2c6c34
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09255101B2

Notizen zur Reaktion

Wird geladen…