Methyl iodide → Methyl 2-(3-bromo-2-methoxyphenyl)acetate

Temperatur

50 °C

To a solution of (3-bromo-2-hydroxy-phenyl)-acetic acid methyl ester (866 mg, 3.5 mmol, 1 eq.) and potassium carbonate (2.44 g, 17.7 mmol, 5 eq.) in MeCN (9 mL), iodomethane (0.67 mL, 10.6 mmol, 3 eq.) was added. The resulting mixture was stirred at 50° C. for 2 hours. The reaction mixture was diluted with AcOEt and water. The layers were separated and the aq. phase was extracted with AcOEt (2×). The comb. org. layers were dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as an orange oil. The product was used without further purification.

1. customThe layers were separated
2. extractionthe aq. phase was extracted with AcOEt (2×)
3. dry with materiallayers were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo

ORD-Eintrag

ord-059b8d3803e1430a89e83f9f1a70f243

Quelldatensatz

uspto-grants-2016_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09255090B2