Ethyl formate → Ethyl 2-(benzyloxy)-3-oxopropanoate

HRID 1774432

Reaktionsgleichung

Reaktionsgleichung von HRID 1774432
[H-].[Na+].[CH:3]([O:5][CH2:6][CH3:7])=[O:4].C([O:10][C:11](=O)[CH2:12][O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)C>CCOCC>[CH2:14]([O:13][CH:12]([CH:11]=[O:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

5

Edukt 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 290299Ethyl 2-(benzyloxy)acetate

Produkt 1

HCID 19903223Ethyl 2-(benzyloxy)-3-oxopropanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a suspension of sodium hydride (3.3 g, 60% in paraffin oil, 82.5 mmol) in dry ether (100 mL) and dry ethyl formate (5.55 g, 75 mmol) was added ethyl(benzyloxy)acetate (14.57 g, 75 mmol) dropwise with stirring. The resulting mixture solution was then refluxed for 2 h and concentrated to give crude ethyl 2-(benzyloxy)-3-oxopropanoate which was used in the subsequent step without further purification.

Aufarbeitung

  1. temperatureThe resulting mixture solution was then refluxed for 2 h
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-20ac485fa36648d1ac8954084203c358
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09260413B2

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