Hydrogen Bromide → 2-(Bromomethyl)-5-(difluoromethoxy)-1,3-difluorobenzene

HRID 1774532

Reaktionsgleichung

Reaktionsgleichung von HRID 1774532
[F:1][CH:2]([F:14])[O:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([CH2:11]O)=[C:6]([F:13])[CH:5]=1.[BrH:15]>C(OCC)C>[Br:15][CH2:11][C:7]1[C:8]([F:10])=[CH:9][C:4]([O:3][CH:2]([F:14])[F:1])=[CH:5][C:6]=1[F:13]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 69140944Benzenemethanol, 4-(difluoromethoxy)-2,6-difluoro-

Produkt 1

HCID 867324312-(Bromomethyl)-5-(difluoromethoxy)-1,3-difluorobenzeneAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

162 mg [4-(difluoromethoxy)-2,6-difluorophenyl]methanol (0.769 mmol, 1.0 eq.) were dissolved in 0.348 mL hydrogen bromide (2.12 mmol, 2.8 eq.). and stirred at rt over night. The reaction mixture was diluted with diethylether and stirred for 5 minutes. The aqueous layer was washed twice with diethylether. The combined organic layers were washed with brine, dried over a silicon filter and concentrated in vacuo to provide the 149 mg (0.51 mmol, 67%) of the crude product, which was used without further purification.

Aufarbeitung

  1. stirringstirred for 5 minutes
  2. washThe aqueous layer was washed twice with diethylether
  3. washThe combined organic layers were washed with brine
  4. customdried over a silicon
  5. filtrationfilter
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-23900a84317847b2bbd04e9318cc8f24
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09260412B2

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