Dimethylformamide → 4-Chloro-2-ethylsulfanylbenzaldehyde

HRID 1775265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1775265
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH2:11]([SH:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([S:13][CH2:11][CH3:12])[CH:3]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 6343EthanethiolHCID 11430Potassium CarbonateHCID 27249084-Chloro-2-fluorobenzaldehyde

Produkt 1

HCID 1148635404-Chloro-2-ethylsulfanylbenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 4.0 g of 4-chloro-2-fluorobenzaldehyde, 2.05 ml of ethanethiol, 3.82 g of potassium carbonate and 6 ml of DMF was stirred at room temperature for 6 hours, and was allowed to stand overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 3.57 g of 4-chloro-2-ethylsulfanylbenzaldehyde. 4-Chloro-2-ethylsulfanylbenzaldehyde

Aufarbeitung

  1. waitto stand overnight
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-da831eea23c848ef89f1c7d1f684dc92
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09260436B2

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