Hydrochloric Acid → 1-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

HRID 1775321Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1775321
[CH3:1][C:2]1[O:6][N:5]=[C:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[N:3]=1.[ClH:20].O1CCOCC1>C(OCC)C>[ClH:20].[CH3:1][C:2]1[O:6][N:5]=[C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[N:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86686046tert-Butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate

Produkt 1

HCID 866860471-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (507 mg, 1.890 mmol) in diethyl ether (12 mL) was added HCl, 4N in dioxane (7 mL, 28.0 mmol) and the reaction was stirred at room temperature over the weekend. The precipitate was isolated by filtration, washed with diethylether and dried under reduced pressure after which 330 mg of a white solid were obtained (1.612 mmol, 85%). MS (ESI) m/z=169.2 [M+1]+.

Aufarbeitung

  1. customThe precipitate was isolated by filtration
  2. washwashed with diethylether
  3. dry with materialdried under reduced pressure after which 330 mg of a white solid
  4. customwere obtained (1.612 mmol, 85%)

Quellen und Nachweise

ORD-Eintrag
ord-d9037ac3eb424c3290e27dfc9adeecb1
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09260441B2

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