Hydromorphone Hydrochloride → Hydromorphone

HRID 17755

Reaktionsgleichung

Reaktionsgleichung von HRID 17755
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15].Cl>O.[O-2].[O-2].[Ti+4]>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15]

Komponenten

4

Edukt 1

HCID 5462347Hydromorphone Hydrochloride

Produkt 1

HCID 5284570Hydromorphone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 162651Titanium oxide (Ti3O)KatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

Drug Loading. Hydromorphone beads were prepared by dissolving hydromorphone HCl in water, adding Opadry Y-5-1442, light pink (a product commercially available from Colorcon, West Point, Pa., which contains hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, polyethylene glycol and D&C Red No. 30 aluminum lake) and mixing for about 1 hour to obtain a 20% w/w suspension. This suspension was then sprayed onto Nu-Pareil 18/20 mesh beads using a Wurster insert.

Aufarbeitung

  1. additionadding Opadry Y-5-1442
  2. additionmixing for about 1 hour
  3. customto obtain a 20% w/w suspension

Quellen und Nachweise

ORD-Eintrag
ord-9c5f8a21995b459d9bee5dd6f95e8e97
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07740881B1

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