1,1'-Carbonyldiimidazole → hexahydroimidazo[1,5-a]pyridin-3(2H)-one

HRID 1775508

Reaktionsgleichung

Reaktionsgleichung von HRID 1775508
C1N=CN([C:6](N2C=NC=C2)=[O:7])C=1.[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH2:19][NH2:20]>C(Cl)Cl>[CH2:19]1[CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][N:13]2[C:6](=[O:7])[NH:20]1

Komponenten

4

Edukt 2

HCID 682631,1'-CarbonyldiimidazoleHCID 90865Piperidine-2-methylamine

Produkt 1

HCID 47002315hexahydroimidazo[1,5-a]pyridin-3(2H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of CDI (830 mg, 5.1 mmol) and piperidin-2-ylmethanamine (520 mg, 4.6 mmol) in DCM (20 mL) was stirred at room temperature overnight. After the solvent was removed, the residue was directly used for the next step without further purification.

Aufarbeitung

  1. customAfter the solvent was removed
  2. customthe residue was directly used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-619ee6518b044e9c8f2128490bba4c10
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09260452B2

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