HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Bromoaniline → 3-(4-Bromophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Bromoaniline | HCID 7807 | — |
| Edukt | Ethyl orthoformate | HCID 31214 | — |
| Edukt | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| Edukt | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 3-(4-Bromophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78320167 | 4% |
Reaktionsschritte
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (200 mg, 0.86 mmol), triethyl orthoformate (2 ml), 4-bromoaniline (280 mg, 1.63 mmol), and acetic acid (0.2 ml) were used to give 13 mg (0.034 mmol, 4% yield) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09260448B2 |
| Quelldatensatz | uspto-grants-2016_02 |
| ORD ID | ord-978c682d0bf0418cbe9a2af5b39bc9e8 |
| Quellennotiz | uspto-grants-2016_02 |