反应详情

In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (200 mg, 0.86 mmol), triethyl orthoformate (2 ml), 4-bromoaniline (280 mg, 1.63 mmol), and acetic acid (0.2 ml) were used to give 13 mg (0.034 mmol, 4% yield) of the title compound.