Potassium Carbonate → HCID 86679497, Verbindung

HRID 1776541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1776541
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:5][C:4]=1[NH:19][S:20]([CH3:23])(=[O:22])=[O:21].Br[CH2:25][C:26]([NH2:28])=[O:27].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[NH2:28][C:26](=[O:27])[CH2:25][N:19]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:3]=1[O:2][CH3:1])[C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])[S:20]([CH3:23])(=[O:22])=[O:21]

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 696322-BromoacetamideHCID 86679496HCID 86679496, Verbindung

Produkt 1

HCID 86679497HCID 86679497, VerbindungAusbeute 94,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Benzyl 4-methoxy-3-(methylsulfonamido)benzoate (200 mg, 0.596 mmol) was dissolved in DMF (2 ml). 2-bromoacetamide (247 mg, 1.789 mmol) and K2CO3 (165 mg, 1.193 mmol) were added, and the reaction was stirred at RT overnight. The reaction mixture was diluted with water and filtered. The precipitate was washed with water and dried in the vacuum oven to give benzyl 3-(N-(2-amino-2-oxoethyl)methylsulfonamido)-4-methoxybenzoate (220 mg, 94% yield).

Aufarbeitung

  1. filtrationfiltered
  2. washThe precipitate was washed with water
  3. customdried in the vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-6eea3b353b88478cb6e8c8b01b8275a8
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09265768B2

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