HCID 86679502, Verbindung → HCID 86679503, Verbindung

HRID 1776547Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1776547
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9]CC2C=CC=CC=2)=[O:8])=[CH:5][C:4]=1[N:19]([CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)[S:20]([CH3:23])(=[O:22])=[O:21]>CO.C(Cl)(Cl)Cl.[Pd]>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[N:19]([CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)[S:20]([CH3:23])(=[O:22])=[O:21]

Komponenten

5

Edukt 1

HCID 86679502HCID 86679502, Verbindung

Produkt 1

HCID 86679503HCID 86679503, VerbindungAusbeute 58,5 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel2×HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Benzyl 4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoate (1.5 g, 3.34 mmol) was dissolved in MeOH (20 ml), then Pd/C 5% (0.33 mmol, 702 mg) was added, and the mixture was hydrogenated in a Parr apparatus (H2:35 psi) for 30 minutes. The reaction was diluted with CHCl3 (300 ml) and MeOH (300 ml) to dissolve the product that precipitated in MeOH, and the catalyst was filtered over a celite pad, and the solvent is evaporated under vacuum, to yield 700 mg of white solid.

Aufarbeitung

  1. dissolutionto dissolve the product that
  2. customprecipitated in MeOH
  3. filtrationthe catalyst was filtered over a celite pad
  4. customthe solvent is evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-1805dc38ee514846a54527a777e199ab
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09265768B2

Notizen zur Reaktion

Wird geladen…