1H-Indazole, 1-methyl-6-nitro- → 1-methyl-1H-indazol-6-amine

HRID 1777114

Reaktionsgleichung

Reaktionsgleichung von HRID 1777114
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[CH:4]=[N:3]1.OCC1(OC[C@@H](O)[C@@H](O)[C@H]1O)O>CCO.C1COCC1.O=[Pt]=O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[CH:4]=[N:3]1

Komponenten

6

Edukt 2

HCID 812901H-Indazole, 1-methyl-6-nitro-HCID 441036D-Psicose

Produkt 1

HCID 8404331-methyl-1H-indazol-6-amineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 1-methyl-6-nitro-1H-indazole (1.2 g, 0.7 mmol) in EtOH (50 ml) and THF (15 ml) was added PtO2 (125 mg) at 26° C. The mixture was stirred for 1.5 h at 26° C. under a H2 atmosphere at 30 Psi. Once the reaction was complete by TLC analysis, the mixture was filtered and the filtrate concentrated to give the target crude product as a white solid which was used in the next step without further purification (1.0 g, Yield 90%). LCMS (m/z): 148.1 (M+1).

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate concentrated
  3. customto give the target crude product as a white solid which
  4. customwas used in the next step without further purification (1.0 g, Yield 90%)

Quellen und Nachweise

ORD-Eintrag
ord-d852d89895ba40cc810ea3a1aebf67ed
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266836B2

Verknüpfte Notizen

Wird geladen…