Benzyl Alcohol → HCID 52463841, Verbindung

HRID 1777752

Reaktionsgleichung

Reaktionsgleichung von HRID 1777752
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8][C:9]([OH:11])=[O:10])[N:3]=1.[CH2:12](O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C1C=CN=CC=1)C.CC#N>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8][C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[N:3]=1

Komponenten

6

Edukt 3

HCID 244Benzyl AlcoholHCID 10868DicyclohexylcarbodiimideHCID 572875(3,5-Dimethyl-1H-pyrazol-1-yl)acetic acid

Produkt 1

HCID 52463841HCID 52463841, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of (3,5-dimethyl-1H-pyrazol-1-yl)acetic acid (600 mg), benzyl alcohol (0.402 mL), DMAP (194 mg) and DCC (802 mg) in MeCN (40 mL) was stirred at RT overnight. The suspension was filtered off and the resulting solution was evaporated to dryness. The residue was purified by CC (Hept/EA 7/3) to afford benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate (460 mg, white solid). LC-MS (B): tR=0.80 min; [M+H]+: 245.18.

Aufarbeitung

  1. filtrationThe suspension was filtered off
  2. customthe resulting solution was evaporated to dryness
  3. customThe residue was purified by CC (Hept/EA 7/3)

Quellen und Nachweise

ORD-Eintrag
ord-bd5d153c9de04fad9880e8f06258083d
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266876B2

Verknüpfte Notizen

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