Pyridine → Phenyl (5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)carbamate

HRID 1777965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1777965
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].[NH2:11][C:12]1[CH:19]=[C:18]([O:20][CH2:21][CH2:22][O:23][CH3:24])[C:15]([C:16]#[N:17])=[CH:14][N:13]=1.N1C=CC=CC=1>C1COCC1>[C:5]1([O:4][C:2](=[O:3])[NH:11][C:12]2[CH:19]=[C:18]([O:20][CH2:21][CH2:22][O:23][CH3:24])[C:15]([C:16]#[N:17])=[CH:14][N:13]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 1180368416-Amino-4-(2-methoxyethoxy)nicotinonitrile2×

Produkt 1

HCID 125470569Phenyl (5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Phenyl chloroformate (4.93 ml, 39.3 mmol) was added drop wise to a mixture of 6-amino-4-(2-methoxyethoxy)nicotinonitrile (intermediate 20, 3.45 g, 17.86 mmol) and pyridine (6.35 ml, 79 mmol) in THF (100 ml) at room temperature. The reaction mixture was stirred for 5 h at room temperature and then partitioned between EtOAc and saturated aqueous NaHCO3 solution, the organic layer washed with saturated brine, dried over MgSO4 and evaporated. The residue was triturated with EtOAc and the product obtained by filtration as a white solid. (UPLC-MS 7) tR 0.97; ESI-MS 314.3 [M+H]+.

Aufarbeitung

  1. custompartitioned between EtOAc and saturated aqueous NaHCO3 solution
  2. washthe organic layer washed with saturated brine
  3. dry with materialdried over MgSO4
  4. customevaporated
  5. customThe residue was triturated with EtOAc
  6. customthe product obtained by filtration as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-00483b89a7344602a1df823fcdb0219c
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266883B2

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