Tert-Butylamine → N-tert-butyl-3-chloropropane-1-sulfonamide

Temperatur

-20 °C

tert-Butylamine (3.0 mol, 315.3 mL) was dissolved in THF (2.5 L). The solution was cooled to −20° C. 3-Chloropropanesulfonyl chloride (1.5 mol, 182.4 mL) was added slowly. The reaction mixture was allowed to warm to rt and stirred for 24 h. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was dissolved in CH2Cl2 (2.0 L). The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) and dried over Na2SO4. It was filtered and concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane to afford the product as a white solid (316.0 g, 99%).

1. temperatureto warm to rt
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated in vacuo
4. dissolutionThe residue was dissolved in CH2Cl2 (2.0 L)
5. washThe resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L)
6. dry with materialdried over Na2SO4
7. filtrationIt was filtered
8. concentrationconcentrated in vacuo
9. customto give a slightly yellow solid, which
10. customwas crystallized from hexane

ORD-Eintrag

ord-4d152abc044543a395564c614ea0d57a

Quelldatensatz

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07741281B2