Sodium Hydroxide → (3,4-Bis(difluoromethoxy)phenyl)methanol

HRID 1780829Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1780829
[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH:7]=[O:8].[BH4-].[Na+].[OH-].[Na+]>C(O)C>[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH2:7][OH:8]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 145092693,4-Bis(difluoromethoxy)benzaldehyde

Produkt 1

HCID 53484633(3,4-Bis(difluoromethoxy)phenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3,4-Bisdifluoromethoxybenzaldehyde (26.2 g, 110 mmol) in absolute ethanol (150 mL) was treated with sodium borohydride (8.32 g, 220 mmol) under an argon atmosphere at room temperature for 0.5 h. Ten percent aqueous sodium hydroxide (130 mL) was added, the ethanol was removed in vacuo, the mixture was partitioned between ether and water and was extracted twice with ether. The organic extract was dried (magnesium sulfate) and evaporated to a pale yellow oil (26.4 g, 100%).

Aufarbeitung

  1. customthe ethanol was removed in vacuo
  2. customthe mixture was partitioned between ether and water
  3. extractionwas extracted twice with ether
  4. extractionThe organic extract
  5. dry with materialwas dried (magnesium sulfate)
  6. customevaporated to a pale yellow oil (26.4 g, 100%)

Quellen und Nachweise

ORD-Eintrag
ord-cdfc92e346f04ad490a7a000c3bd4b4c
Quelldatensatz
uspto-grants-1997_05
Patentnummer
US05631286

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