Sodium Hydroxide → HCID 54134609, Verbindung

HRID 1780839Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1780839
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])C=O)[CH2:3][CH2:2]1.[BH4-].[Na+].[OH-:20].[Na+]>C(O)C>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([OH:20])[CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 189736983-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

Produkt 1

HCID 54134609HCID 54134609, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Crude 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde (26.4 g) in absolute ethanol (200 mL) was treated with sodium borohydride (8.23 g, 217 mmol) under an argon atmosphere at room temperature for 0.33 h. Ten percent aqueous sodium hydroxide (150 mL) was added, the ethanol was removed in vacuo and the aqueous residue was extracted three times with ether. The organic extract was washed twice with brine, was dried (sodium sulfate), was filtered and was evaporated to a pale yellow oil (24.4 g).

Aufarbeitung

  1. customthe ethanol was removed in vacuo
  2. extractionthe aqueous residue was extracted three times with ether
  3. extractionThe organic extract
  4. washwas washed twice with brine
  5. dry with materialwas dried (sodium sulfate)
  6. filtrationwas filtered
  7. customwas evaporated to a pale yellow oil (24.4 g)

Quellen und Nachweise

ORD-Eintrag
ord-4456a194c8a0409daf7209caa3d8ab35
Quelldatensatz
uspto-grants-1997_05
Patentnummer
US05631286

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