Hydrochloric Acid → 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([C:13]([O:15]C)=[O:14])[C:5]2[O:11][CH2:10][CH2:9][CH2:8][O:7][C:6]=2[CH:12]=1.[OH-].[K+].Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[C:5]2[O:11][CH2:10][CH2:9][CH2:8][O:7][C:6]=2[CH:12]=1Komponenten
5
Versuchsvorschrift
A mixture of intermediate (5) (0.25 mol) and KOH (1 mol) in water (650 ml) was stirred and refluxed for 2 hours. The reaction mixture was cooled, acidified with HCl and the resulting precipitate was filtered off, washed with water, and dried, yielding 48 g of 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid (intermediate 6).
Aufarbeitung
- temperaturerefluxed for 2 hours
- temperatureThe reaction mixture was cooled
- filtrationthe resulting precipitate was filtered off
- washwashed with water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-6c5f9646199d45d58af408ff2c6e6383
- Quelldatensatz
- uspto-grants-2009_03
- Patentnummer
- US07498347B2
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