Water → HCID 86613843, Verbindung

HRID 1782620Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1782620
C([NH:4][C:5]1[CH:10]=[C:9]([I:11])[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[C:6]=1[Cl:16])(=O)C.C(Cl)(=O)C.O>CO>[NH2:4][C:5]1[CH:10]=[C:9]([I:11])[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[C:6]=1[Cl:16]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 86613844HCID 86613844, Verbindung

Produkt 1

HCID 86613843HCID 86613843, VerbindungAusbeute 78,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To solution of 4-acetylamino-3-chloro-6-iodopyridine-2-carboxylic acid, methyl ester (5.0 g, 14 mmol) in methanol (25 mL) was added acetyl chloride (1 mL) and the solution heated under reflux for 1 hour. The solution was cooled and water (25 mL) added and the precipitate was collected. Recrystallization from methanol gave 4-amino-3-chloro-6-iodopyridine-2-carboxylic acid, methyl ester (3.5 g, 11 mmol) mp 152-153° C.

Aufarbeitung

  1. temperaturethe solution heated
  2. temperatureunder reflux for 1 hour
  3. temperatureThe solution was cooled
  4. customthe precipitate was collected
  5. customRecrystallization from methanol

Quellen und Nachweise

ORD-Eintrag
ord-934967c86b6e4b24b3451998f1aebc3d
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07498468B2

Notizen zur Reaktion

Wird geladen…