Reaktionsgleichung
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[N:9]=[C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=1)=[O:4].[C:19]1(/[CH:25]=[CH:26]/[CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:24]=[CH:23][CH:22]=CC=1.C(N(CC)[CH:38]([CH3:40])[CH3:39])(C)C.[C:43](#N)C>>[C:38]([C:24]1[CH:23]=[CH:22][C:26]([CH2:27][N:28]2[CH2:29][CH2:30][N:31]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[C:10]([Cl:12])[N:9]=[C:8]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[N:7]=3)=[O:4])[CH2:32][CH2:33]2)=[CH:25][CH:19]=1)([CH3:40])([CH3:43])[CH3:39]Komponenten
5
Versuchsvorschrift
To a stirred solution of 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (0.80 g in 40 ml acetonitrile) was added [(2E)-3-phenylprop-2-enyl]piperazine (0.50 g in 10 ml acetonitrile). After 3 hrs, N,N-diisopropylethylamine was added (428 μl in 10 ml acetonitrile) and the reaction stirred for a further 2 hrs after which time a precipitate of the title compound appeared. This was used crude in the next step.
Quellen und Nachweise
- ORD-Eintrag
- ord-672ef598fb674a0f9bd424ca5278f4f3
- Quelldatensatz
- uspto-grants-2009_03
- Patentnummer
- US07501407B2
Verknüpfte Notizen
Wird geladen…