Potassium Carbonate → HCID 16788087, Verbindung

HRID 1783751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1783751
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[N:11]1(C(O)=O)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.[C:20]([O-])([O-:22])=[O:21].[K+].[K+].CN1C(=O)CCC1>O>[N+:8]([C:7]1[C:2]([N:11]2[CH2:12][CH2:13][CH:14]([C:20]([OH:22])=[O:21])[CH2:15][CH2:16]2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

Komponenten

6

Edukt 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 796132-Chloro-3-nitropyridineHCID 9964094Piperidine-1-carboxylic acid

Produkt 1

HCID 16788087HCID 16788087, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The mixture consisting of 634 mg of 2-chloro-3-nitropyridine, 620 mg of piperidine carboxylic acid, 820 mg of potash and 3 ml of NMP was stirred at 80° C. for 2 hours. After allowing to cool, 30 ml of water of water were added and the crude product was extracted with 30 ml of ethyl acetate. After drying the organic phase with sodium sulfate, it was concentrated under reduced pressure.

Aufarbeitung

  1. temperatureto cool
  2. extractionthe crude product was extracted with 30 ml of ethyl acetate
  3. dry with materialAfter drying the organic phase with sodium sulfate, it
  4. concentrationwas concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-167c65b36ef045c2878dd95c113c12bc
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07501440B2

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