2-Chloro-5-nitrobenzenesulfonamide → 2-Cyclopropylamino-5-nitrobenzenesulphonamide

HRID 17838

Reaktionsgleichung

Reaktionsgleichung von HRID 17838
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[S:11]([NH2:14])(=[O:13])=[O:12].[CH:15]1([NH2:18])[CH2:17][CH2:16]1>O1CCOCC1>[CH:15]1([NH:18][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[S:11]([NH2:14])(=[O:13])=[O:12])[CH2:17][CH2:16]1

Komponenten

4

Edukt 2

HCID 667842-Chloro-5-nitrobenzenesulfonamideHCID 69828Cyclopropylamine

Produkt 1

HCID 675301582-Cyclopropylamino-5-nitrobenzenesulphonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2-Chloro-5-nitrobenzenesulphonamide (5 g) prepared in the Step above is introduced into a hermetically closed vessel containing a mixture of dioxane (70 mL) and cyclopropylamine (3.5 mL). The hermetically closed vessel is placed in an oven at 100° C. for 24 hours. After this time period, the solvent and the reagent are removed by concentrating under reduced pressure. The residue is taken up in methanol (20 mL) and the insoluble material, which contains the title product, is collected by filtration, washed with methanol and dried.

Aufarbeitung

  1. additionabove is introduced into a hermetically closed vessel
  2. additioncontaining
  3. customAfter this time period, the solvent and the reagent are removed
  4. concentrationby concentrating under reduced pressure
  5. filtrationis collected by filtration
  6. washwashed with methanol
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-cc7cdf4d90fc4c72980716ddfe9808c6
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741320B2

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