Ethylorthoformate → 4-cyclopropyl-7-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide

HRID 17839

Reaktionsgleichung

Reaktionsgleichung von HRID 17839
[CH:1]1([NH:4][C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=2[S:14]([NH2:17])(=[O:16])=[O:15])[CH2:3][CH2:2]1.[CH:18]([O-])([O-])OCC>>[CH:1]1([N:4]2[C:5]3[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=3[S:14](=[O:16])(=[O:15])[N:17]=[CH:18]2)[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 53630039EthylorthoformateHCID 675301582-Cyclopropylamino-5-nitrobenzenesulphonamide

Produkt 1

HCID 675307714-cyclopropyl-7-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

In a round-bottom flask, a mixture of 2-cyclopropylamino-5-nitrobenzenesulphonamide (5 g), originating from the Step above, and ethyl orthoformate (50 mL) is heated in the open state at 130° C. for 3 hours. The suspension obtained is cooled on an ice bath and the insoluble material is collected by filtration, washed with ether and dried.

Aufarbeitung

  1. customThe suspension obtained
  2. temperatureis cooled on an ice bath
  3. filtrationthe insoluble material is collected by filtration
  4. washwashed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d3c399511b97447abf51faf290d79fe9
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741320B2

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