Pyridine → HCID 178433931, Verbindung

HRID 1786703

Reaktionsgleichung

Reaktionsgleichung von HRID 1786703
[O:1]=[C:2]1[C:7]([C:8]([NH:10][NH2:11])=O)=[CH:6][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:4][NH:3]1.[C:18]([NH2:21])(=S)[CH3:19].C(N(CC)CC)C.N1C=CC=CC=1>C(O)CCC>[CH3:19][C:18]1[NH:21][C:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[C:5]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[CH:6]=2)=[N:10][N:11]=1

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 8471TriethylamineHCID 2723949ThioacetamideHCID 127902392,3-Dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid hydrazide

Produkt 1

HCID 178433931HCID 178433931, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

A mixture of 100 mg of 3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carboxylic acid hydrazide, 130 mg thioacetamide, 87 mg triethylamine, 1 ml of pyridine and 5 ml of butanol is refluxed for 15 hours. After cooling and stirring at room temperature, a solid precipitated is collected by filtration, washed with cold isopropanol and dried in vacuo.

Aufarbeitung

  1. temperatureis refluxed for 15 hours
  2. temperatureAfter cooling
  3. customa solid precipitated
  4. filtrationis collected by filtration
  5. washwashed with cold isopropanol
  6. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9975cf0fb56142daa5f77fd28abbd97c
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07507734B2

Verknüpfte Notizen

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