6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one → HCID 68487141, Verbindung
Reaktionsgleichung
[CH2:1]([N:3]1[C:8](=[O:9])[C:7]2=[N:10][O:11][C:12]([CH3:13])=[C:6]2[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4]1)[CH3:2]>[Pd].C(O)C>[C:12]([C:6]1[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[N:4][N:3]([CH2:1][CH3:2])[C:8](=[O:9])[C:7]=1[NH2:10])(=[O:11])[CH3:13]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A mixture of 6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one (Dal Piaz, V et al., J. Med. Chem. 1997, 40, 1417) (2.0 g, 7.83 mmol) and 10% palladium on charcoal (400 mg) in ethanol (400 mL) was shaken under hydrogen at room temperature and 2 bar for 3 h. The catalyst was filtered off and the solvent was removed under reduced pressure to yield the title compound (98% yield).