HCID 57599641, Verbindung → HCID 57599653, Verbindung

HRID 1787542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1787542
[CH3:1][O:2][C:3]1[C:4]([N+:15]([O-])=O)=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][O:13][CH3:14])[C:6]#[N:7]>[Pd].C(O)C>[NH2:15][C:4]1[C:3]([O:2][CH3:1])=[C:10]([O:11][CH2:12][O:13][CH3:14])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

Komponenten

4

Edukt 1

HCID 57599641HCID 57599641, Verbindung

Produkt 1

HCID 57599653HCID 57599653, VerbindungAusbeute 53,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To 5% palladium on activated carbon 6.00 g under argon atmosphere was added a solution of 3-methoxy-4-(methoxymethoxy)-2-nitrobenzonitrile 6.00 g (25.2 mmol) in ethanol 50 mL and stirred under hydrogen atmosphere at room temperature for 8 hours. The reaction mixture was filtrated and the filtrate was concentrated in vacuo. Silica gel chromatography (n-hexane/AcOEt=4/1) afforded the title compound 2.83 g as white solid. Yield 53.9%.

Aufarbeitung

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-899aa86cc1f143a3bcb3c3b76ed12120
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07511041B2

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