1-Amino-2-propanol → HCID 12384307, Verbindung

HRID 1787861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1787861
[NH2:1][CH2:2][CH:3]([OH:5])[CH3:4].[C:6]1(=O)[O:11][C:9](=[O:10])[C:8]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:7]12.C(N(CC)CC)C.C1(C)C=CC=CC=1>O>[CH2:6]([O:11][C:9]([NH:1][CH2:2][CH:3]([OH:5])[CH3:4])=[O:10])[C:7]1[CH:8]=[CH:12][CH:13]=[CH:14][CH:15]=1

Komponenten

6

Edukt 4

HCID 41-Amino-2-propanolHCID 1140TolueneHCID 6811Phthalic AnhydrideHCID 8471Triethylamine

Produkt 1

HCID 12384307HCID 12384307, VerbindungAusbeute 142,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a round bottom flask equipped with Dean-Stark trap was added (1) (2 g, 7.4 mmol), phthalic anhydride (1.1 g, 7.4 mmol), triethylamine (0.1 mL) and toluene (50 mL). The reaction mixture was heated to reflux and water produced was collected. After refluxing for 2 hours, the solvent was removed. The residue was acidified using 1 N HCl, filtered and washed with water, dried to give 2.2 g of (2). 1H NMR (DMSO-d6, 400 MHz): δ 7.8 (m, 4H), 7.3 (m, 5H), 7.1 (d, 2H), 6.8 (d, 2H), 5.05 (m, 1H), 3.3 (m, 2H).

Aufarbeitung

  1. customTo a round bottom flask equipped with Dean-Stark trap
  2. temperatureThe reaction mixture was heated
  3. temperatureto reflux
  4. customwas collected
  5. temperatureAfter refluxing for 2 hours
  6. customthe solvent was removed
  7. filtrationfiltered
  8. washwashed with water
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2b99da6e97b8436a8959456d82cfddc4
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07511063B2

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