Water → Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

HRID 1788404

Reaktionsgleichung

Reaktionsgleichung von HRID 1788404
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2].[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.O>C(#N)C>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([NH:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7965CyclohexylamineHCID 1268247Ethyl 4-chloro-3-nitrobenzoate

Produkt 1

HCID 5298559Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of Compound 9 (22.96 g, 100 mmol), cyclohexylamine (15.31 g, 154 mmol) and TEA (13.57 g, 134 mmol) in 100 mL acetonitrile was refluxed overnight. The reaction mixture was poured into icy water and the precipitated crystals were collected by means of filtration, washed three times with water then was dried over phosphorous pentoxide in high vacuum to yield Compound 10.

Aufarbeitung

  1. filtrationthe precipitated crystals were collected by means of filtration
  2. washwashed three times with water
  3. dry with materialthen was dried over phosphorous pentoxide in high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f5e0bd8ff69a4e21abafde0eae58e9a5
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07511145B2

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