4-Piperidineethanol → HCID 13336380, Verbindung

HRID 1788740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1788740
[C:1]1([C:7]2[N:16]=[C:15]([C:17]([O:19]CC)=O)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:22]1[CH2:27][CH2:26][CH:25]([CH2:28][CH2:29][OH:30])[CH2:24][CH2:23]1>O>[C:1]1([C:7]2[N:16]=[C:15]([C:17]([N:22]3[CH2:27][CH2:26][CH:25]([CH2:28][CH2:29][OH:30])[CH2:24][CH2:23]3)=[O:19])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 739534-PiperidineethanolHCID 20158356HCID 20158356, Verbindung

Produkt 1

HCID 13336380HCID 13336380, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Ethyl 2-phenylquinazoline-4-carboxylate (1.7 g) and piperidine-4-ethanol (8 g) are heated at 150° C. for 4 hours. After cooling, water is added and the mixture is extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and evaporated to dryness under reduced pressure. The residue is chromatographed on silica gel with ethyl acetate as the eluant, and the product recovered is recrystallised from isopropyl ether. This gives 1-[(2-phenylquinazoline-4-yl)carbonyl]-piperidine-4-ethanol (0.5 g), melting at 146° C.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionthe mixture is extracted with ethyl acetate
  3. dry with materialThe organic phase is dried over magnesium sulphate
  4. customevaporated to dryness under reduced pressure
  5. customThe residue is chromatographed on silica gel with ethyl acetate as the eluant
  6. customthe product recovered
  7. customis recrystallised from isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-dadf8d7dde1b4f6bbc1fb4ee0a4ec3a0
Quelldatensatz
uspto-grants-1987_08
Patentnummer
US04684652

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