Hydrochloric Acid → HCID 13770520, Verbindung

HRID 1788945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1788945
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:21]3([CH3:26])OCC[O:22]3)[CH:19]=2)[N:14]([CH2:27][CH3:28])[C:13]1=[O:29])=[O:11].O1CCCC1.Cl>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:21](=[O:22])[CH3:26])[CH:19]=2)[N:14]([CH2:27][CH3:28])[C:13]1=[O:29])=[O:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 13770519HCID 13770519, Verbindung

Produkt 1

HCID 13770520HCID 13770520, VerbindungAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

N-(2,4-Difluorophenyl)-1-ethyl-5-(2-methyl-4,5-dihydro-1,3-dioxol-2-yl)oxindol-3-carboxamide (636 mg., 1.58 mmoles) was dissolved in 15 ml. of tetrahydrofuran to which was added 10 ml. of 1N hydrochloric acid. The solution was stirred for one hour followed by the addition of an equal volume of water. The resulting precipitate was filtered, vacuum dried and recrystallized from diisopropyl ether - methylene chloride, 412 mg. (73% yield), m.p. 160°-161° C.

Aufarbeitung

  1. filtrationThe resulting precipitate was filtered
  2. customvacuum dried
  3. customrecrystallized from diisopropyl ether - methylene chloride, 412 mg

Quellen und Nachweise

ORD-Eintrag
ord-853080dc47954cab85e3613655c71d91
Quelldatensatz
uspto-grants-1987_08
Patentnummer
US04686224

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