7-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one → 7-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

HRID 1790488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1790488
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2=[O:13])=[CH:5][CH:4]=1.[BH4-].[Na+]>CO>[OH:13][CH:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=2)[CH2:7][CH2:8][CH2:9]1

Komponenten

4

Edukt 2

HCID 812767-Methoxy-1,2,3,4-tetrahydronaphthalen-1-oneHCID 4311764Sodium borohydride

Produkt 1

HCID 122431977-Methoxy-1,2,3,4-tetrahydronaphthalen-1-olAusbeute 102,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

7-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one (5 g) was dissolved in methanol and sodium tetrahydroborate (1.3 g) was added thereto at 0° C. After reacting at room temperature for 2 hr, the reaction solution was partitioned between ethyl acetate and water. The ethyl acetate layer was washed with water, dried and concentrated under reduced pressure to give the title compound (5.19 g) as a colorless oil. (280-2) 1-(4-Acetylpiperazin-1-yl)-7-methoxy-1,2,3,4-tetrahydronaphthalene

Aufarbeitung

  1. customat 0° C
  2. customthe reaction solution was partitioned between ethyl acetate and water
  3. washThe ethyl acetate layer was washed with water
  4. customdried
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f37e7763df2441269aa380f4b809c0ab
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07071201B2

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