Sodium Acetate → 1-(2-Methyl-1,3-dioxolan-2-YL)cyclopropane-1-carbaldehyde

HRID 1790879Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1790879
[CH3:1][C:2]1([C:7]2([CH2:10][OH:11])[CH2:9][CH2:8]2)[O:6][CH2:5][CH2:4][O:3]1.C([O-])(=O)C.[Na+].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[CH3:1][C:2]1([C:7]2([CH:10]=[O:11])[CH2:9][CH2:8]2)[O:3][CH2:4][CH2:5][O:6]1

Komponenten

5

Edukt 3

HCID 517045Sodium AcetateHCID 22042312[1-(2-Methyl-1,3-dioxolan-2-yl)cyclopropyl]methanolHCID 178418287HCID 178418287, Verbindung

Produkt 1

HCID 143755571-(2-Methyl-1,3-dioxolan-2-YL)cyclopropane-1-carbaldehydeAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

10 g of 6 is dissolved in 500 ml of dichloromethane, and 3.7 g of sodium acetate and 19.3 g of pyridinium chlorochromate are added at room temperature under nitrogen. After 3 hours at room temperature, it is filtered on silica gel, concentrated by evaporation, diluted with diethyl ether, filtered again, and the solvent is removed, whereby 7.8 g of title compound 7 is obtained as a colorless oil.

Aufarbeitung

  1. filtrationit is filtered on silica gel
  2. concentrationconcentrated by evaporation
  3. additiondiluted with diethyl ether
  4. filtrationfiltered again
  5. customthe solvent is removed

Quellen und Nachweise

ORD-Eintrag
ord-57f9bc4b3818405e91fe86ee9d699db9
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07071344B1

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