1,4-Dibromo-2-nitrobenzene → 4-Bromo-2-nitrobenzonitrile
Reaktionsgleichung
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12]([Cu])#[N:13]>CC(N(C)C)=O.CCOC(C)=O>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([C:12]#[N:13])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Stir the mixture of 1,4-dibromo-2-nitro-benzene (3.56 mmol)and CuCN (3.74 mmol) in DMA (4 ml) at 100° C. for 5hours. Cool to room temperature, dilute with EtOAc, filter through celite, wash the organic layer with brine, dry over Na2SO4, and concentrate under vacuum. Purify the residue by flash chromatography (4:1 hexanes/EtOAc) to give 4-bromo-2-nitro-benzonitrile.
Aufarbeitung
- filtrationfilter through celite
- washwash the organic layer with brine
- dry with materialdry over Na2SO4
- concentrationconcentrate under vacuum
- customPurify the residue by flash chromatography (4:1 hexanes/EtOAc)
Quellen und Nachweise
- ORD-Eintrag
- ord-4080763d33fc4969b23659b3cd2ed48e
- Quelldatensatz
- uspto-grants-2006_07
- Patentnummer
- US07074799B2
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