Allyl bromide → 7-Allyl-8-chloro-3-methyl-3,7-dihydropurine-2,6-dione

HRID 1791993Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1791993
[Cl:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:20](Br)[CH:21]=[CH2:22]>CN(C)C=O.C(OCC)(=O)C.O>[CH2:22]([N:10]1[C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=[C:2]1[Cl:1])[CH:21]=[CH2:20]

Komponenten

7

Edukt 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 126175848-chloro-3-methyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione

Produkt 1

HCID 220295197-Allyl-8-chloro-3-methyl-3,7-dihydropurine-2,6-dione

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

8-Chloro-3-methyl-3,7-dihydropurine-2,6-dione (868 mg) and potassium carbonate (628 mg) were suspended in N,N-dimethylformamide (10 ml), and allyl bromide was added dropwise thereto while cooling on ice. After stirring the reaction mixture at room temperature for 17 hours, the resulting white suspension was diluted with ethyl acetate (30 ml) and water (4 ml), and was filtered to give a white solid. The solid was washed with water and ethyl acetate to give 797 mg of the title compound.

Aufarbeitung

  1. temperaturewhile cooling on ice
  2. filtrationwas filtered
  3. customto give a white solid
  4. washThe solid was washed with water and ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-eba40e1b03a04e9bac81fafb421d9fb6
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07074798B2

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