Hydrazine hydrate (1:1) → 6-Bromoquinazoline-4-carboxylic acid hydrazide

HRID 1792500Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1792500
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]([O:14]C)=O.O.[NH2:17][NH2:18]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]([NH:17][NH2:18])=[O:14]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 22031300Methyl 6-bromoquinazoline-4-carboxylate

Produkt 1

HCID 235376576-Bromoquinazoline-4-carboxylic acid hydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 961 mg methyl 6-bromoquinazoline-4-carboxylate (compound in Production Example 413), 0.9 mL hydrazine monohydrate and 70 mL methanol was stirred at room temperature for 30 minutes, and the precipitated crystals were collected by filtration. The filtrate was evaporated to give additional crystals. The title compound, 838 mg in total, was obtained as pale yellow crystals.

Aufarbeitung

  1. filtrationthe precipitated crystals were collected by filtration
  2. customThe filtrate was evaporated
  3. customto give additional crystals

Quellen und Nachweise

ORD-Eintrag
ord-b96e73a1e56e4329afd9d3fefcac5524
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07074801B1

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