Sodium Hydroxide → 1-Butanol, 2-(4-pyrimidinylamino)-

HRID 1793083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1793083
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10][OH:11])[CH:3]=1.[OH-].[Na+]>C(O)C.[Pd]>[N:7]1[CH:2]=[CH:3][C:4]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10][OH:11])=[N:5][CH:6]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 22024413HCID 22024413, Verbindung

Produkt 1

HCID 220243971-Butanol, 2-(4-pyrimidinylamino)-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysator2×HCID 702EthanolLösungsmittel

Versuchsvorschrift

2-[(6-Chloro-4-pyrimidinyl)amino]-1-butanol was dissolved in ethanol (110 mL), which was sequentially added with a 5N aqueous sodium hydroxide solution (5.5 mL) and Pd—C (hydrous product; 0.55 g), and hydrogenation was performed under hydrogen atmosphere at a normal temperature and a normal pressure. After completion of the reaction, Pd—C was filtered off, and the solvent was evaporated. The resulting residue was extracted with dichloromethane-methanol, and the solvent was removed to give the title compound (4.3 g) as white crystals.

Aufarbeitung

  1. filtrationwas filtered off
  2. customthe solvent was evaporated
  3. extractionThe resulting residue was extracted with dichloromethane-methanol
  4. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-7aeaa9b5e887432ea2aa67e82af68d84
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07078405B2

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