Ethanol → Ethanol water glycerin glycerol monooleate

HRID 1793268

Reaktionsgleichung

Reaktionsgleichung von HRID 1793268
[CH2:1]([OH:3])[CH3:2].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>O.OCC(CO)O>[CH2:1]([OH:3])[CH3:2].[OH2:22].[OH:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Komponenten

5

Edukt 2

HCID 702EthanolHCID 5283468Glyceryl Monooleate

Produkt 1

HCID 131716747Ethanol water glycerin glycerol monooleate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 753GlycerolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

95% ethanol (USP) was diluted with water (USP), glycerin (USP), and glycerol monooleate (Eastman Chemical, Kingsport N.Y.) to provide a final solution at ethanol/water/glycerin/glycerol monooleate percent ratios of 35/59/5/1, respectively. Oxybutynin free base was then dissolved into the above solution to a concentration of 10 mg/gram. The resultant solution was then gelled with 1% hydroxypropyl cellulose (Aqualon, Wilmington, Del.) to provide a final oxybutynin gel. One to two grams of the above gel is applied topically to approximately 200 cm2 surface area on the chest, torso, and or arms to provide topical administration of oxybutynin.

Quellen und Nachweise

ORD-Eintrag
ord-88fa344a52a84607aa162aa511c4c43b
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07081250B2

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