Propylamine → HCID 10083151, Verbindung

HRID 1793491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1793491
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([NH2:10])[CH2:8][CH3:9].[CH:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][C:12]=1[O:21][CH2:22][CH2:23][CH2:24]Cl>CS(C)=O.O>[CH2:7]([NH:10][CH2:24][CH2:23][CH2:22][O:21][C:12]1[CH:13]=[CH:14][C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:11]=1)[CH2:8][CH3:9]

Komponenten

6

Edukt 3

HCID 7852PropylamineHCID 11430Potassium CarbonateHCID 116872053-(2-Naphthyloxy)-1-chloropropane

Produkt 1

HCID 10083151HCID 10083151, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
145 °C

Versuchsvorschrift

A mixture of anhydrous potassium carbonate (10 gm, in excess) and n-propylamine (0.28 ml, 0.003 mole) was taken in dry DMSO (40 ml). Now 3-(2-naphthyloxy)-1-chloropropane (0.5 gm, 0.002 mole) was added in it. Reaction mixture was refluxed at 145° C. for 8 hrs and the reaction was completed as checked by TLC. Reaction mixture was poured in distilled water (60 ml) and extracted with ethyl acetate thrice. The organic layer was separated and concentrated to get oily compound which was later crystallized by benzene hexane to get N-(n-propyl-(3-(naphthalen-2-yloxy)propyl)amine, solid, m.p. 112° C., (yield 0.51 gm, 91.2%).

Aufarbeitung

  1. customReaction mixture
  2. customReaction mixture
  3. extractionextracted with ethyl acetate thrice
  4. customThe organic layer was separated
  5. concentrationconcentrated
  6. customto get oily compound which
  7. customwas later crystallized by benzene hexane

Quellen und Nachweise

ORD-Eintrag
ord-b3102b1a1d544a3ebb6092b02e0c3ca2
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07081465B2

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