Water → 2-(1H-Tetrazol-1-YL)benzonitrile

HRID 1795262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1795262
[N:1]1([C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]([NH2:10])=O)[CH:5]=[N:4][N:3]=[N:2]1.[OH-].COC(NS([NH3+])(=O)=O)=O.O>O1CCCC1>[N:1]1([C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]#[N:10])[CH:5]=[N:4][N:3]=[N:2]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 8559562-(1H-Tetrazol-1-YL)benzamideHCID 21866229(Methoxycarbonylsulfamoyl)ammonium hydroxide

Produkt 1

HCID 218662732-(1H-Tetrazol-1-YL)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-tetrazol-1-yl-benzamide (1.5 g, 7.9 mmol) in tetrahydrofuran (50 ml) was added (methoxycarbonylsulfamoyl)ammonium hydroxide, inner salt (2.8 g, 11.8 mmol) in three portions over 1.5 h. Water was added and the reaction mixture was extracted with ethyl acetate. The combined organic layers were washed with brine. Drying and solvent evaporation gave 2-tetrazol-1-yl-benzonitrile; 1H NMR (CDCl3, 400 MHz) δ 9.27 (s, 1H), 7.90 (m, 3H), 7.72 (m, 1H).

Aufarbeitung

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washThe combined organic layers were washed with brine
  3. customDrying
  4. customsolvent evaporation

Quellen und Nachweise

ORD-Eintrag
ord-d3bb02b339414d488e0a204054e12d78
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07026324B2

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