2-(1H-1,2,4-triazol-1-yl)Benzonitrile → [2-(1H-1,2,4-triazol-1-yl)phenyl]methanamine
Reaktionsgleichung
[N:1]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]#[N:13])[CH:5]=[N:4][CH:3]=[N:2]1>[Pd].C(O)C>[N:1]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:12][NH2:13])[CH:5]=[N:4][CH:3]=[N:2]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 2-(1,2,4-triazol-1-yl)cyanobenzene (508 mg, 2.99 mmol) and 25% by weight of palladium on carbon, 10% catalyst (134 mg) in ethanol (75 ml) was placed on a PARR hydrogenation Apparatus under a hydrogen atmosphere at 55 psi. overnight. The mixture was filtered through celite and concentrated to give 2-(1,2,4-triazol-1-yl)-benzylamine; 1H NMR (CD3OD) δ 8.80 (s, 1H), 8.22 (s, 1H), 7.64–7.43 (m, 4H), 3.66 (s, 2H).
Aufarbeitung
- customovernight
- filtrationThe mixture was filtered through celite and
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-c998bdb8cb354b2bba79fc424cb38620
- Quelldatensatz
- uspto-grants-2006_04
- Patentnummer
- US07026324B2
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