Hydrochloric Acid → 7-Chloromethylimidazo[1,2-alpha]pyrimidine hydrochloride

HRID 1796100Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1796100
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[N:6][C:5]=12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)Br.[ClH:36]>ClCCl>[ClH:36].[Cl:36][CH2:10][C:7]1[CH:8]=[CH:9][N:4]2[CH:3]=[CH:2][N:1]=[C:5]2[N:6]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 18001293Imidazo[1,2-a]pyrimidin-7-ylmethanol

Produkt 1

HCID 695607647-Chloromethylimidazo[1,2-alpha]pyrimidine hydrochlorideAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of imidazo[1,2-α]pyrimidin-7-ylmethanol (4.64 g, 34.1 mmol) in dichloromethane under an atmosphere of nitrogen was added triphenylphosphine (10.6 g, 40.5 mmol) and carbon tetrabromide (13.4 g, 40.5 mmol). This mixture was stirred at room temperature for 2.5 h before addition of ethereal hydrogen chloride (1.0M, 100 ml) in a dropwise manner and allowed to stir at room temperature for a further 1 h. Reaction mixture was evaporated to dryness under reduced pressure and the resulting solid washed with dichloromethane followed by ether and then dried under vacuum to give 7-chloromethylimidazo[1,2-α]pyrimidine hydrochloride salt (5.0 g, 79%) as a pale brown solid: δH (360 MHz, d6-DMSO) 5.06 (2H, s), 7.77 (1H, d, J 7), 8.31-8.35 (2H, m), 9.37 (1H, d, J 7); m/z (ES+) 168, 170 (M++H).

Aufarbeitung

  1. customReaction mixture
  2. customwas evaporated to dryness under reduced pressure
  3. washthe resulting solid washed with dichloromethane
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-1effa26c71ed41f9a4c44508a890591f
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030128B2

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