Trifluoroacetic acid → 2-Amino-1-oxazolo[4,5-b]pyridin-2-yl-butan-1-ol TFA salt

HRID 1796139

Reaktionsgleichung

Reaktionsgleichung von HRID 1796139
C(OC(=O)[NH:7][C@H:8]([CH:11]([OH:21])[C:12]1[O:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:9][CH3:10])(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[NH2:7][CH:8]([CH2:9][CH3:10])[CH:11]([C:12]1[O:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2)[OH:21]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 21048468(S)-[1-(hydroxy-oxazolo[4,5-b]pyridin-2-yl-methyl)-propyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 865883392-Amino-1-oxazolo[4,5-b]pyridin-2-yl-butan-1-ol TFA salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(S)-[1-(Hydroxy-oxazolo[4,5-b]pyridin-2-yl-methyl)-propyl]-carbamic acid tert-butyl ester (311 mg, 1 mmol) and MeCl2 (5 ml) were mixed and TFA (1 ml) was added at room temperature. After stirring for 1 hour, the solvent and excess TFA were removed under vacuum to produce 355 mg of 2-Amino-1-oxazolo[4,5-b]pyridin-2-yl-butan-1-ol TFA salt.

Aufarbeitung

  1. customthe solvent and excess TFA were removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d901b6c8fd29471daa906a9c3c9733c2
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030116B2

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